Uji Analgetik Infus Daun Jambu Biji Berdaging Merah pada Mencit Jantan dengan Metode Rangsangan Kimia

  • Hery Prambudi Akademi Analis Kesehatan An-Nasher Cirebon, Indonesia
Keywords: Analgesic, Chemical stimulation method, Male mice, Red fleshly guava leaves

Abstract

The flavonoids content on guava leaves has a role to improve blood circulation throughout the body and prevent the occurrence of blood vessel blockage, anti-inflammatory and analgesic. This study aims to determine whether the infusion of red fleshy guava leaves (Psidium guajava Linn.) has an analgesic effect on male mice (Mus musculus) and at what concentration the infusion of red fleshy guava leaves (Psidium guajava Linn.) has an analgesic effect on male mice (Mus musculus). The experiments were carried out using chemical stimulation methods. Analgesics or painkillers are substances that reduce or eliminate pain without losing consciousness (the difference with general anesthesia). This research is a pure experimental study using 25 mice divided into 5 treatment groups, each group consisting of 5 mice, then induced with 1% v / v acetic acid dose 50 mg / kgBB intraperitonially (ip) as pain induction, left for 15 minutes. then the treatment was carried out in each concentration group of 10% w / v, 15% w / v, and 20% w / v. Oral administration of 1% paracetamol suspension solution at a dose of 65 mg / kgBW was used as a positive control, and aquadest was used as a negative control. observations were made by counting the amount of writhing seen in 5 minutes for 60 minutes, then determined the percentage of analgesic power. The results showed that the infusion of red fleshy guava leaves (Psidium guajava Linn.) had an analgesic effect of the percentage of analgesic power of 87.88% which was close to the percentage of paracetamol analgesic power of 100%.

Catatan Penerbit
Polekkes Kemenkes Kendari menyatakan tetap netral sehubungan dengan klaim dari perspektif atau buah pikiran yang diterbitkan dan dari afiliasi institusional manapun.

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References

Anggraeni, F. H. (2010). Uji analgetik ekstrak etanol daun sambiloto (andrographis paniculata nees) pada mencit betina swiss dengan metode rangsangan kimia [Universitas Sanata Dharma]. https://repository.usd.ac.id/17279/2/068114125_Full.pdf

Anggraini, W. (2008). Efek antiinflamasi ekstrak etanol daun jambu biji (psidium guajava linn) pada tikus putih jantan galur wistar [Universitas Muhammadiyah Surakarta]. http://eprints.ums.ac.id/id/eprint/1429

Dalimartha, S. (2003). Atlas tumbuhan obat indonesia (3rd ed.). Trubus Agriwidya. https://onesearch.id/Record/IOS3326.INLIS000000000001206

Desiyana, L. S., Husni, M. A., & Zhafira, S. (2016). Uji efektivitas sediaan gel fraksi etil asetat daun jambu biji (psidium guajava linn) terhadap penyembuh luka terbuka pada mencit (mus musculus). Jurnal Natural, 16(2). https://doi.org/https://doi.org/10.24815/jn.v16i2.5017

Dewi, I. D. A. D. ., Astuti, K. ., & Warditiani, N. . (2013). Identifikasi kandungan kimia ekstrak kulit buah manggis (garcinia mangostana l.). Jurnal Farmasi Udayana, 2(4). https://scholar.google.com/scholar_lookup?title=Identifikasi kandungan kimia ekstrak kulit buah manggis (garcinia mangostana l.)

Dwitiyanti, D. (2015). Daun jambu biji (psidium guajaba l.) sebagai antikaner payudara. Pharmaceutical Sciences and Research, 2(2), 79–88. https://doi.org/10.7454/psr.v2i2.3323

Hanum, M. (2011). Pengobatan tradisional dengan jamu ala kraton sebagai warisan turun temurun. Andi. https://onesearch.id/Record/IOS3605.JATEN-05120000000044#description

Inayati, A. (2010). Uji efek analgetik dan antiinflamasi ekstrak etanol 70% daun sirih (piper betle linn) secara in vivo [Universitas Islam Negeri Syarif Hidayatullah]. http://repository.uinjkt.ac.id/dspace/bitstream/123456789/1211/1/ALFI INAYATI-FKIK.PDF

Muliyanti, S. (2010). Uji efek analgetik kombinasi infus bandotan (ageratum conyzoides l.) dan temu mangga (curcuma mangga val.&zijp.) pada mencit [Universitas Indonesia]. http://lib.ui.ac.id/file?file=digital/2016-8/20181438-S33185-Siti Muliyanti.pdf

Mutschler, E. (1991). Dinamika obat: buku ajar farmakologi dan toksikologi (Mathilda B. Widianto, Anna Setiadi Ranti, & Kosasi Padmawinata (eds.); V). ITB. https://onesearch.id/Record/IOS4813.INLIS000000000045490

Nuraini, D. N. (2014). Aneka daun berkhasiat untuk obat. Gava Media. https://onesearch.id/Record/IOS1.INLIS000000000722887

Poeloengan, M. (2010). Uji Aktivitas Antibakteri Ekstrak Kulit Buah Manggis (Garcinia mangostana Linn). Media Penelitian Dan Pengembangan Kesehatan, 20(2). http://repository.litbang.kemkes.go.id/1408/

Purwati, S., Lumowa, S. V. ., & Samsurianto, S. (2017). Skrining fitokimia daun saliara (lantana camara l) sebagai pestisida nabati penekan hama dan insiden penyakit pada tanaman holtikultura di kalimantan timur. Prosiding Seminar Kimia, 153–158. https://scholar.google.com/scholar_lookup?title=Skrining fitokimia daun saliara (lantana camara l) sebagai pestisida nabati penekan hama dan insiden penyakit pada tanaman holtikultura di kalimantan timur

Puspitasari, H., Listyawati, S., & Widiyanti, T. (2003). Aktivitas Analgetik Ekstrak Umbi Teki (Cyperus rotundus L.) pada Mencit Putih (Mus musculus L.) Jantan. Biofarmasi, 1(2). https://doi.org/10.13057/biofar/f010203

Sariana, S. (2011). Uji Efek Analgetik dari Infusa Daun Asam Jawa (Tamarindus Indica Linn) pada Mencit (Mus Musculus) [Universitas Islam Negeri Alauddin Makassar]. http://repositori.uin-alauddin.ac.id/3338/

Tuhu, P. F. S. (2008). Efek analgetika ekstrak etanol daun kayu putih (melaleuca leucadendron l) pada mencit jantan [Universitas Muhammadiyah Surakarta]. https://scholar.google.com/scholar_lookup?title=Efek analgetika ekstrak etanol daun kayu putih (melaleuca leucadendron l) pada mencit jantan

Wulandari, D., & Hendra, P. (2011). Efek analgesik infusa daun macarangan tanarius l pada mencit betina galur swiss. Bionatura, 13(2). https://scholar.google.com/scholar_lookup?title=Efek analgesik infusa daun macarangan tanarius l pada mencit betina galur swiss

Published
2020-06-30
How to Cite
Prambudi, H. (2020). Uji Analgetik Infus Daun Jambu Biji Berdaging Merah pada Mencit Jantan dengan Metode Rangsangan Kimia. Health Information : Jurnal Penelitian, 12(1), 76-85. https://doi.org/10.36990/hijp.vi.168
Section
Articles