Aktivitas Antihiperurisemia Ekstrak Tanaman Jelatang (Urtica dioca L.) pada Mencit





Allopurinol, Gout, Hyperuricemia, Jelatang


Hyperuricemia is a high level of uric acid in the blood and can cause gout. One of the drugs used to treat hyperuricemia is allopurinol. The use of these drugs can cause various side effects if used for a long period of time. Nettle plants are known to contain flavonoids which can reduce uric acid levels in the blood. This study was conducted to test the activity of nettle plants and to find out the effective dose in reducing blood uric acid levels in mice. In this study, extracts were made using maceration method using 70% ethanol. Tests were carried out on mice induced by pottasium oxonate and chicken liver juice to increase uric acid levels. Then the test animals were divided into 5 groups cosisted of the negative control group (0.5% NaCMC), positive control (allopurinol 13mg/kgBW), the dose I group (125mg/kgBW), dose II (250mg/kgBW), and dose III (500mg/kgBW). Next step is to measured the decrease of uric acid levels in mice’s blood every hour for 5 hours. Then the data of decreased in uric acid levels were processed statistically using the Anova and Duncan method. Based on the results of test in mice, nettle extract has antihyperuricemia activity with successive doses of 500 mg/kgBW (89.91%), 250 mg/kgBW (73.7%), and 125mg/kgBW (63.56%).

Catatan Penerbit
Polekkes Kemenkes Kendari menyatakan tetap netral sehubungan dengan klaim dari perspektif atau buah pikiran yang diterbitkan dan dari afiliasi institusional manapun.

Penelitian ini didanai oleh Universitas Perjuangan Tasikmalaya.


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Abdullah, Angelina, Yumna, M., Arbianti, R., Utami, T. S., Hermansyah, H., & Ningsih, S. (2018). Flavonoid isolation and identification of mother-in-law’s tongue leaves (sansevieria trifasciata) and the inhibitory activities to xanthine oxidase enzyme. E3S Web of Conferences. https://doi.org/10.1051/e3sconf/20186703011

Abu-Gharbieh, E., Shehab, N. G., Almasri, I. M., & Bustanji, Y. (2018). Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations. PLoS ONE. https://doi.org/10.1371/journal.pone.0202572

Besral, B., & Widiantini, W. (2015). Determinan Stres pada Pegawai Kementerian Kesehatan Republik Indonesia. Kesmas: National Public Health Journal. https://doi.org/10.21109/kesmas.v9i3.568

Carvalho, A. R., Costa, G., Figueirinha, A., Liberal, J., Prior, J. A. V., Lopes, M. C., Cruz, M. T., & Batista, M. T. (2017). Urtica spp.: Phenolic composition, safety, antioxidant and anti-inflammatory activities. Food Research International. https://doi.org/10.1016/j.foodres.2017.06.008

Corp, N., & Pendry, B. (2013). The role of Western herbal medicine in the treatment of gout. Journal of Herbal Medicine. https://doi.org/10.1016/j.hermed.2013.08.002

Dar, S. A., Ganai, F. A., Yousuf, A. R., Balkhi, M. U. H., Bhat, T. M., & Sharma, P. (2013). Pharmacological and toxicological evaluation of Urtica dioica. Pharmaceutical Biology. https://doi.org/10.3109/13880209.2012.715172

Farag, M. A., Weigend, M., Luebert, F., Brokamp, G., & Wessjohann, L. A. (2013). Phytochemical, phylogenetic, and anti-inflammatory evaluation of 43 Urtica accessions (stinging nettle) based on UPLC-Q-TOF-MS metabolomic profiles. Phytochemistry. https://doi.org/10.1016/j.phytochem.2013.09.016

Gansser, D., & Spiteller, G. (1995). Aromatase inhibitors from Urtica dioica roots. Planta Medica. https://doi.org/10.1055/s-2006-958033

Grace, L. B. (2012). Goodman and gillman. In Elsevier.

Hou, C., Liu, D., Wang, M., Gong, C., Li, Y., Yang, L., Yao, M., Yuan, E., & Ren, J. (2019). Novel xanthine oxidase-based cell model using HK-2?cell for screening antihyperuricemic functional compounds. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2019.04.007

Ilyas, M., Daud, N. S., & Aqmarina, M. (2019). Aktivitas Antihiperurisemia Ekstrak Etanol Daun Galing (Cayratia trifolia L. Domin) Pada Mencit BALB/C. WARTA FARMASI. https://doi.org/10.46356/wfarmasi.v8i2.88

Katzung, & Trevor’s. (2015). Pharmacology Examination & Board Review. In Mc Graw Hill Educarion. https://doi.org/10.1007/978-1-4614-1174-1_13

Kratzer, J. T., Lanaspa, M. A., Murphy, M. N., Cicerchi, C., Graves, C. L., Tipton, P. A., Ortlund, E. A., Johnson, R. J., & Gaucher, E. A. (2014). Evolutionary history and metabolic insights of ancient mammalian uricases. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1320393111

Maiuolo, J., Oppedisano, F., Gratteri, S., Muscoli, C., & Mollace, V. (2016). Regulation of uric acid metabolism and excretion. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2015.08.109

Modarresi-Chahardehi, A., Ibrahim, D., Sulaiman, S. F., & Mousavi, L. (2012). Screening antimicrobial activity of various extracts of Urtica Dioica. Revista de Biologia Tropical. https://doi.org/10.15517/rbt.v60i4.2074

Obertreis, B., Giller, K., Teucher, T., Behnke, B., & Schmitz, H. (1996). [Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid]. Arzneimittel-Forschung. https://scholar.google.com/scholar_lookup?title=Anti-inflammatory%20effect%20of%20Urtica%20dioica%20folia%20extract%20in%20comparison%20to%20caffeic%20malic%20acid

Salih, N. A. (2015). Effect of nettle (Urtica dioica) extract on gentamicin induced nephrotoxicity in male rabbits. Asian Pacific Journal of Tropical Biomedicine. https://doi.org/10.1016/j.apjtb.2015.07.005

Setty, A. R., & Sigal, L. H. (2005). Herbal medications commonly used in the practice of rheumatology: Mechanisms of action, efficacy, and side effects. Seminars in Arthritis and Rheumatism. https://doi.org/10.1016/j.semarthrit.2005.01.011



How to Cite

Fadilah, N. N. ., & Susanti, S. (2020). Aktivitas Antihiperurisemia Ekstrak Tanaman Jelatang (Urtica dioca L.) pada Mencit. Health Information : Jurnal Penelitian, 12(1), 99-106. https://doi.org/10.36990/hijp.vi.193