Kajian Teoritis Hubungan antara Depresi dengan Sistem Neuroimun

Lilin Rosyanti; Reni Devianti Usman; Indriono Hadi; Syahrianti Syahrianti

doi:10.36990/hijp.v9i2.104

Authors

Lilin Rosyanti Jurusan Keperawatan, Poltekkes Kemenkes Kendari, Indonesia, Indonesia
Reni Devianti Usman Jurusan Keperawatan, Poltekkes Kemenkes Kendari, Indonesia, Indonesia
Indriono Hadi Jurusan Keperawatan, Poltekkes Kemenkes Kendari, Indonesia, Indonesia https://orcid.org/0000-0003-1783-8806
Syahrianti Jurusan Kebidanan, Poltekkes Kemenkes Kendari, Indonesia, Indonesia

DOI:

https://doi.org/10.36990/hijp.v9i2.104

Keywords:

Cytokine, Depression, Stress, Psychoneuroimmunologic

Abstract

Depression is an affective, physiologic, cognitive and behavioral disorder that affects regular behaviors and reactions. Depression is an inflammation. Psychoneuroimmunology is a discipline that explores the relationships between the nervous system and immunity and behavior and wellbeing. The emphasis is primarily on the immunological and psychological stress response. The reciprocal direction of contact between nerve, endocrine, and immune systems is suggested by psychoneuroimmunologic studies. In mental illnesses, the immune system is active. Cytokines can develop into depressive disorders in susceptible patients. In infancy trauma as a depression vulnerability. In certain regions of the brain, including the hippocampo, there is an increase in glucocorticoids that is more likely to cause damage in the presence of disturbances in the control of neuro endo cratic responses of patients with depressed HPA axis hyperactivity triggered by hypersecretion of the hypothalamic hormone peptide corticotropin (CRH). The complex relationship between stress, immune and neuroendocrine has been shown by inflammation and the cytokines, which play an important role in controlling the association between stress and depression. The pro-inflammatory cytokines that respond to stress and answers in patients are increased by psychological stress.

References

Anisman, H., Merali, Z., & Hayley, S. (2008). Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depresi and neurodegenerative disorders. Prog Neurobiol, 85(1), 1-74. https://doi.org/10.1016/j.pneurobio.2008.01.004

Baune, B. (2009). Conceptual challenges of a tentative model of stress-induced depresi. PLoS One, 4(1), e4266. https://doi.org/10.1371/journal.pone.0004266

Becking, K., Spijker, A. T., Hoencamp, E., Penninx, B. W., Schoevers, R. A., & Boschloo, L. (2015). Disturbances in Hypothalamic-Pituitary-Adrenal Axis and Immunological Activity Differentiating between Unipolar and Bipolar Depressive Episodes. PLoS One, 10(7), e0133898. https://doi.org/10.1371/journal.pone.0133898

Capuron, L., & Miller, A. H. (2004). Cytokines and psychopathology: lessons from interferon-alpha. Biol Psychiatry, 56(11), 819-824. https://doi.org/10.1016/j.biopsych.2004.02.009

Capuron, L., Pagnoni, G., Drake, D. F., Woolwine, B. J., Spivey, J. R., Crowe, R. J., . . . Miller, A. H. (2012). Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa admtersebutstration. Arch Gen Psychiatry, 69(10), 1044-1053. https://doi.org/10.1001/archgenpsychiatry.2011.2094

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depresi: when the immune system subjugates the brain. Nat Rev Neurosci, 9(1), 46-56. https://doi.org/10.1038/nrn2297

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctot, K. L. (2010). A meta-analysis of cytokines in major depresi. Biol Psychiatry, 67(5), 446-457. https://doi.org/10.1016/j.biopsych.2009.09.033

D'Mello, C., Le, T., & Swain, M. G. (2009). Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci, 29(7), 2089-2102. https://doi.org/10.1523/jneurosci.3567-08.2009

Dantzer, R. (2007). Psychoneuroimmunology* A2 - Fink, George Encyclopedia of Stress (Second Edition) (pp. 284-287). New York: Academic Press. https://doi.org/10.1016/B978-012373947-6.00318-4

Dantzer, R., & Kelley, K. W. (2007). Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun, 21(2), 153-160. https://doi.org/10.1016/j.bbi.2006.09.006

de Kloet, E. R., Derijk, R. H., & Meijer, O. C. (2007). Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depresi? Nat Clin Pract Endocrinol Metab, 3(2), 168-179. https://doi.org/10.1038/ncpendmet0403

Duggal, N. A., Upton, J., Phillips, A. C., Hampson, P., & Lord, J. M. (2015). NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression. Age (Dordr), 37(1), 9748. https://doi.org/10.1007/s11357-015-9748-2

Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J., . . . Whiteford, H. A. (2013). Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med, 10(11), e1001547. https://doi.org/10.1371/journal.pmed.100154

Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005). The pathogenesis of cltersebutcal depresi: stressor- and cytokine- induced alterations of neuroplasticity. Neuroscience, 135(3), 659-678. https://doi.org/10.1016/j.neuroscience.2005.03.051

Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008). The link between childhood trauma and depresi: insights from HPA axis penelitianes in humans. Psychoneuroendocrinology, 33(6), 693-710. https://doi.org/10.1016/j.psyneuen.2008.03.008

Ida, M., Ida, I., Wada, N., Sohmiya, M., Tazawa, M., & Shirakura, K. (2013). A clinical study of the efficacy of a single session of individual exercise for depressive patients, assessed by the change in saliva free cortisol level. Biopsychosoc Med, 7(1), 18. https://doi.org/10.1186/1751-0759-7-18

Irwin, M. R., & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav Immun, 21(4), 374-383. https://doi.org/10.1016/j.bbi.2007.01.01

Ising, M., Kunzel, H. E., Binder, E. B., Nickel, T., Modell, S., & Holsboer, F. (2005). The combined dexamethasone/CRH test as a potential surrogate marker in depresi. Prog Neuropsychopharmacol Biol Psychiatry, 29(6), 1085-1093. https://doi.org/10.1016/j.pnpbp.2005.03.014

Keller, M. C., Neale, M. C., & Kendler, K. S. (2007). Association of different adverse life events with distinct patterns of depressive symptoms. Am J Psychiatry, 164(10), 1521-1529; quiz 1622. https://doi.org/10.1176/appi.ajp.2007.06091564

Kleiner, G., Marcuzzi, A., Zanin, V., Monasta, L., & Zauli, G. (2013). Cytokine levels in the serum of healthy subjects. Mediators Inflamm, 2013, 434010. https://doi.org/10.1155/2013/434010

Kondziella, D., Alvestad, S., Vaaler, A., & Sonnewald, U. (2007). Which cltersebutcal and experimental data link temporal lobe epilepsy with depresi? J Neurochem, 103(6), 2136-2152. https://doi.org/10.1111/j.1471-4159.2007.04926.x

Kunugi, H., Hori, H., Adachi, N., & Numakawa, T. (2010). Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depresi. Psychiatry Clin Neurosci, 64(5), 447-459. https://doi.org/10.1111/j.1440-1819.2010.02135.x

Loftis, J. M., Huckans, M., & Morasco, B. J. (2010). Neuroimmune mechanisms of cytokine-induced depresi: current theories and novel treatment strategies. Neurobiol Dis, 37(3), 519-533. https://doi.org/10.1016/j.nbd.2009.11.015

Maletic, V., Robinson, M., Oakes, T., Iyengar, S., Ball, S. G., & Russell, J. (2007). Neurobiology of depresi: an integrated view of key findings. Int J Clin Pract, 61(12), 2030-2040. https://doi.org/10.1111/j.1742-1241.2007.01602.x

Moica, T., Grecu, I. G., Moica, S., Grecu, M. G., & Buicu, G. E. (2016). Cortisol and Hippocampal Volume as Predictors of Active Suicidal Behavior in Major Depressive Disorder: Case Report. Balkan Med J, 33(6), 706-708. https://doi.org/10.5152/balkanmedj.2016.150842

Miller, A. H., Haroon, E., Raison, C. L., & Felger, J. C. (2013). Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety, 30(4), 297-306. https://doi.org/10.1002/da.22084

Miller, A. H., Maletic, V., & Raison, C. L. (2009). Inflammation and its discontents: the role of cytokines in the pathophysiology of major depresi. Biol Psychiatry, 65(9), 732-741. https://doi.org/10.1016/j.biopsych.2008.11.029

Neumeister, A., Wood, S., Bonne, O., Nugent, A. C., Luckenbaugh, D. A., Young, T., . . . Drevets, W. C. (2005). Reduced hippocampal volume in unmedicated, remitted patients with major depresi versus control subjects. Biol Psychiatry, 57(8), 935-937. https://doi.org/10.1016/j.biopsych.2005.01.016

Pariante, C. M. (2009). Risk factors for development of depresi and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids. Ann N Y Acad Sci, 1179, 144-152. https://doi.org/10.1111/j.1749-6632.2009.04978.x

Pariante, C. M., & Lightman, S. L. (2008). The HPA axis in major depresi: classical theories and new developments. Trends Neurosci, 31(9), 464-468. https://doi.org/10.1016/j.tins.2008.06.006

Pariante, C. M., & Miller, A. H. (2001). Glucocorticoid receptors in major depresi: relevance to pathophysiology and treatment. Biol Psychiatry, 49(5), 391-404.

Pineda, E., Shin, D., Sankar, R., & Mazarati, A. M. (2010). Comorbidity between epilepsy and depresi: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. Epilepsia, 51 Suppl 3, 110-114. https://doi.org/10.1111/j.1528-1167.2010.02623.x

Quan, N., & Banks, W. A. (2007). Brain- immune communication pathways. Brain Behav Immun, 21(6), 727-735. https://doi.org/10.1016/j.bbi.2007.05.005

Raison, C. L., Capuron, L., & Miller, A. H. (2006). Cytokines sing the blues: inflammation and the pathogenesis of depresi. Trends Immunol, 27(1), 24-31. https://doi.org/10.1016/j.it.2005.11.006

Raison, C. L., & Miller, A. H. (2011). Is depresi an inflammatory disorder? Curr Psychiatry Rep, 13(6), 467-475. https://doi.org/10.1007/s11920-011-0232-0

Shelton, R. C., Claiborne, J., Sidoryk- Wegrzynowicz, M., Reddy, R., Aschner, M., Lewis, D. A., & Mirnics, K. (2011). Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depresi. Mol Psychiatry, 16(7), 751-762. https://doi.org/10.1038/mp.2010.52

Spijker, A. T., & van Rossum, E. F. (2012). Glucocorticoid sensitivity in mood disorders. Neuroendocrinology, 95(3), 179-186. https://doi.org/10.1159/000329846

Wieseler-Frank, J., Maier, S. F., & Watkins, L. R. (2005). Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences. Brain Behav Immun, 19(2), 104-111.

Ventura-Junca, R., Symon, A., Lopez, P., Fiedler, J. L., Rojas, G., Heskia, C., . . . Herrera, L. (2014). Relationship of cortisol levels and genetic polymorphisms to antidepressant response to placebo and fluoxetine in patients with major depressive disorder: a prospective study. BMC Psychiatry, 14, 220. https://doi.org/10.1186/s12888-014-0220-0

Walker, E. R., McGee, R. E., & Druss, B. G. (2015). Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry, 72(4), 334-341. https://doi.org/10.1001/jamapsychiatry.2014.2502

Warner-Schmidt, J. L., Vanover, K. E., Chen, E. Y., Marshall, J. J., & Greengard, P. (2011). Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci USA, 108(22), 9262-9267. https://doi.org/10.1073/pnas.1104836108

Yirmiya, R., & Goshen, I. (2011). Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun, 25(2), 181-213. https://doi.org/10.1016/j.bbi.2010.10.015

Yirmiya, R., Pollak, Y., Morag, M., Reichenberg, A., Barak, O., Avitsur, R., . . . Pollmacher, T. (2000). Illness, cytokines, and depression. Ann N Y Acad Sci, 917, 478-487. https://doi.org/10.1111/j.1749-6632.2000.tb05412.x

Zhu, C. B., Lindler, K. M., Owens, A. W., Daws, L. C., Blakely, R. D., & Hewlett, W. A. (2010). Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology, 35(13), 2510-2520. https://doi.org/10.1038/npp.2010.116

Zobel, A., Wellmer, J., Schulze-Rauschenbach, S., Pfeiffer, U., Schnell, S., Elger, C., & Maier, W. (2004). Impairment of inhibitory control of the hypothalamic pituitary adrenocortical system in epilepsy. Eur Arch Psychiatry Clin Neurosci, 254(5), 303-311. https://doi.org/10.1007/s00406-004-0499-9

Zunszain, P. A., Anacker, C., Cattaneo, A., Carvalho, L. A., & Pariante, C. M. (2011). Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry, 35(3), 722-729. https://doi.org/10.1016/j.pnpbp.2010.04.011

Zunszain, P. A., Hepgul, N., & Pariante, C. M. (2013). Inflammation and depression. Curr Top Behav Neurosci, 14, 135-151. https://doi.org/10.1007/7854_2012_211