The Effect of Polyhexamethylene Biguanide Compress on Biofilm in Diabetic Ulcers

Miranti Lestari; Husni Husni; Hendri Heriyanto; Mardiani Mardiani; Sahran Sahran; Idramsyah Idramsyah

doi:10.36990/hijp.v18i2.1850

Authors

Miranti Lestari Jurusan Keperawatan, Poltekkes Kemenkes Bengkulu, Indonesia
Husni Husni Jurusan Keperawatan, Poltekkes Kemenkes Bengkulu, Indonesia
Hendri Heriyanto Jurusan Keperawatan, Poltekkes Kemenkes Bengkulu, Indonesia
Mardiani Mardiani Jurusan Keperawatan, Poltekkes Kemenkes Bengkulu, Indonesia
Sahran Sahran Jurusan Keperawatan, Poltekkes Kemenkes Bengkulu, Indonesia
Idramsyah Idramsyah Jurusan Keperawatan, Poltekkes Kemenkes Bengkulu, Indonesia

DOI:

https://doi.org/10.36990/hijp.v18i2.1850

Keywords:

Diabetic Foot Ulcer, Biofilm, Polyhexamethylene Biguanide, Wound Care

Abstract

Latar belakang: Biofilm merupakan salah satu faktor utama yang menghambat penyembuhan ulkus diabetikum dan meningkatkan risiko infeksi kronis. Polyhexamethylene biguanide (PHMB) diketahui memiliki aktivitas antibiofilm yang potensial dalam perawatan luka modern. Tujuan: Menganalisis pengaruh kompres PHMB terhadap biofilm pada ulkus diabetikum di Klinik Alfacare Center Kota Bengkulu. Metode: Penelitian kuantitatif dengan desain quasi-experiment menggunakan pretest–posttest with control group. Sampel berjumlah 44 responden yang dibagi menjadi kelompok intervensi (n=22) dan kelompok kontrol (n=22) melalui teknik purposive sampling. Biofilm diukur menggunakan lembar observasi biofilm tervalidasi. Analisis data menggunakan uji Wilcoxon dan Mann–Whitney. Hasil: Rerata skor biofilm kelompok intervensi turun dari 6,86±0,94 menjadi 2,41±0,50, dan kelompok kontrol dari 7,27±0,83 menjadi 4,45±0,90. Penurunan signifikan pada kedua kelompok (p=0,0001; p=0,001), dan uji Mann–Whitney menunjukkan kompres PHMB berpengaruh signifikan (p=0,001). Kesimpulan: Kompres PHMB berpengaruh signifikan dalam menurunkan biofilm pada ulkus diabetikum fase proliferasi. Saran: PHMB dapat direkomendasikan sebagai bagian dari perawatan luka modern untuk pengendalian biofilm pada ulkus diabetikum

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