Efek Analgetik Ekstrak Daun Gatal (Laportea decumana (Roxb.) Wedd) Pada Mencit (Mus Muscullus L.)

Abstract

Abstract

The stinging tree (Laportea decumana (Roxb.) Wedd) is one of the typical Papuan plants used to relieve pain or pain. Stinging trees in their use are still traditionally by rubbing the leaves directly on the painful parts of the body (abdomen, hands, feet, head, etc.) and only among the Papuan people. Thus, there is a need for research related to testing the analgesic effects of stinging tree extract on mice test animals so that they can be further developed into medicinal preparations that are safe for use by the public. The purpose of this study was to determine the analgesic effect and effective dosage of itch leaf extract in male mice. The experimental research method used 25 male mice divided into five groups, negative control Na-CMC 1%, acetosal 1%, and stinging tree extract doses 250, 500, and 1000 mg/kg. The results showed that stinging tree extract doses of 250mg, 500mg, and 1000mg/kg had an analgesic effect (0.000<0.05), and the most effective dose was 1000mg/kg. The conclusion of stinging tree extract (Laportea decumana (Roxb.) Wedd) has an analgesic effect.

Keywords: Stinging tree, painful, writhing test.