POEMS Syndrome: Latest Comprehensive Review

Abstract

Background: POEMS syndrome includes polyneuropathy, organomegaly, endocrinopathies, M protein, and skin changes. POEMS syndrome is a rare disorder with a mean age of onset between 46 and 56 years. Progressive POEMS syndrome can cause severe cardiorespiratory compromise, in some patients resulting in premature death. Early and aggressive diagnosis and treatment is required. Purpose: there are not many recent reviews describing POEMS syndrome, so the author wants to bring together various related literature and provide the latest references regarding POEMS syndrome. Method: Various related literature was retrieved over a period of 3 (three) years using the Google Scholar database, PubMed, Cochrane Library with the keyword "POEMS Syndrome". The analysis and arrangement of the study was carried out after fulfilling the inclusion and exclusion criteria. Results: POEMS syndrome is a rare paraneoplastic syndrome due to an underlying plasma cell abnormality. Neuropathy which is the main characteristic and important criterion for diagnosis. The POEMS Syndrome Diagnostic Criteria can be used to help establish the diagnosis. Conclusion: The right diagnosis can provide appropriate management so that good long-term clinical results are obtained.