Neuroprotector Effects of Moringa Leaf (Moringa Oleifera Lamk) Ethanol Extract on Type Two Diabetes Rats Induced by Streptozotocin-Nicotinamid
DOI:
https://doi.org/10.36990/hijp.v14i2.719Keywords:
Moringa oleifera Lamk, Neurotoxic, Neuroprotector, AntihyperglycemicAbstract
Moringa leaf (Moringa Oleifera Lamk) has been widely used as an alternative therapy for diabetes mellitus, supported by scientific evidence. However, the effect of moringa leaves on diabetic neuropathy has not been studied. This study aims to determine the timing of the occurrence of diabetic neuropathy and the neuroprotective activity of moringa leaf extract on streptozotocin-nicotinamide (STZ-NA) induction. STZ-NA was induced intra peritoneal for three days to obtain hyperglycemic conditions in rats, while reducing the amount of foods in test animals was carried out to get the nutritional deficiencies that will accelerate the occurrence of diabetic neuropathy. Intra peritoneal injection of 65 mg/kg bb STZ and 150 mg/kg bb NA were performed and observed until diabetic neuropathy occurred. Extract ethanol of Moringa leaf was given orally after the test animals had diabetic neuropathy on day 28 with doses of 50,100 and 150 mg/kg bb. Glibenclamide, Vitamin B6, Glibenclamide + vitamin B6 were used as medicines control. As result, lack of nutrition can accelerate the occurrence of diabetic neuropathy. Moringa leaf ethanol extract dose of 100, 150 mg/kg bb gave better activity than glibenclamide, but it’s not better than glibenclamide+vitamin B6. Diabetic neuropathy in malnourished rats occurred on day 28 after STZ-NA induction. The most potent dose of ethanol extract of moringa leaves to be developed as a neuroprotector is a dose of 150 mg/kg bb.
References
Acute and Chronic Complications. (2017). Diabetes, 66(Supplement_1), A101–A173. https://doi.org/10.2337/db17
-663
Bjerg, L., Gudbjörnsdottir, S., Franzén, S., Carstensen, B., Witte, D. R., Jørgensen, M. E., & Svensson, A.-M. (2021).
Duration of diabetes-related complications and mortality in type 1 diabetes: A national cohort study.
International Journal of Epidemiology, 50(4), 1250–1259. https://doi.org/10.1093/ije/dyaa290
Castelli, G., Desai, K. M., & Cantone, R. E. (2020). Peripheral Neuropathy: Evaluation and Differential Diagnosis.
American Family Physician, 102(12), 732–739.
they
Colvin, L. A., & Dougherty, P. M. (2015). Peripheral neuropathic pain: Signs, symptoms, mechanisms, and causes:
are
linked?
BJA:
https://doi.org/10.1093/bja/aeu323
British
Journal
of
Anaesthesia,
(3),
–363.
Haber, S. L., McMahon, R. P., Barajas, J., Hayes, A. R., & Hussein, H. (2020). Effects of Moringa oleifera in patients
with type 2 diabetes. American Journal of Health-System Pharmacy, 77(22), 1834–1837.
https://doi.org/10.1093/ajhp/zxaa255
Harding, J. L., Pavkov, M. E., Magliano, D. J., Shaw, J. E., & Gregg, E. W. (2019). Global trends in diabetes
complications:
A review of current evidence. Diabetologia,
https://doi.org/10.1007/s00125-018-4711-2
(1),
–16.
Matschinsky, F. M., & Wilson, D. F. (2019). The Central Role of Glucokinase in Glucose Homeostasis: A Perspective
Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans. Frontiers in
Physiology, 10. https://doi.org/10.3389/fphys.2019.00148
Santos Jr, A. R., Nascimento, V. A., Genari, S. C., Lombello, C. B., Jr, A. R. S., Nascimento, V. A., Genari, S. C., &
Lombello, C. B. (2014). Mechanisms of Cell Regeneration—From Differentiation to Maintenance of
Cell
Phenotype.
In
Cells
and
Biomaterials
in
Regenerative
Medicine.
IntechOpen.
Vargas-Sánchez, K., Garay-Jaramillo, E., & González-Reyes, R. E. (2019). Effects of Moringa oleifera on Glycaemia
and Insulin Levels: A Review of Animal and Human Studies. Nutrients, 11(12), Article 12.
https://doi.org/10.3390/nu11122907
Yapanis, M., James, S., Craig, M. E., O’Neal, D., & Ekinci, E. I. (2022). Complications of Diabetes and Metrics of
Glycemic Management Derived From Continuous Glucose Monitoring. The Journal of Clinical
Endocrinology & Metabolism, 107(6), e2221–e2236. https://doi.org/10.1210/clinem/dgac034
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