Perbandingan Efek Pemberian Salep Ekstrak Daun Binahong (Anredera Cordifolia (Tenore) Steenis) Dan Salep Silver Sulfadiazine 1% Pada Penyusutan Luka Bakar Derajat Ii Tikus Putih Jantan (Rattus Norvegicus)

Abstract

Burns is tissue damage caused by high heat, chemical compounds, electricity, radioactivation and excessive exposure to sunlight. Binahong leaves contain flavonoids, saponins, ascorbic acid, ursolic acid, and oleanolat acid which increase angiogenesis and stimulate collagen formation which plays a role in the wound healing process. The purpose of this study was to prove the effect of binahong leaf extract on healing second degree burns. This study uses the Post Test Only Control Group Design method. The sample used in the study was 25 rats. The samples were divided into 5 groups, namely given ointment base (K), given Binahong leaf extract (P1), given Binahong leaf extract 20% (P2), given Binahong leaf extract 40% (P3) , and given 1% silver sulfadiazine ointment (P4), treated for 30 days. The data were analyzed using the Repeated measure ANOVA test and then continued with the Tukey statistical test. The repeated measure ANOVA showed significant differences between each treatment group (P-value 0.000). Tukey's test results showed a significant P-value in the 20% binahong leaf extract group (P2) compared to other groups. The conclusion was that 20% binahong leaf extract affected on reducing the burn surface area.