Kajian Teoritis Hubungan antara Depresi dengan Sistem Neuroimun
DOI:
https://doi.org/10.36990/hijp.v9i2.104Keywords:
Cytokine, Depression, Stress, PsychoneuroimmunologicAbstract
Depression is an affective, physiologic, cognitive and behavioral disorder that affects regular behaviors and reactions. Depression is an inflammation. Psychoneuroimmunology is a discipline that explores the relationships between the nervous system and immunity and behavior and wellbeing. The emphasis is primarily on the immunological and psychological stress response. The reciprocal direction of contact between nerve, endocrine, and immune systems is suggested by psychoneuroimmunologic studies. In mental illnesses, the immune system is active. Cytokines can develop into depressive disorders in susceptible patients. In infancy trauma as a depression vulnerability. In certain regions of the brain, including the hippocampo, there is an increase in glucocorticoids that is more likely to cause damage in the presence of disturbances in the control of neuro endo cratic responses of patients with depressed HPA axis hyperactivity triggered by hypersecretion of the hypothalamic hormone peptide corticotropin (CRH). The complex relationship between stress, immune and neuroendocrine has been shown by inflammation and the cytokines, which play an important role in controlling the association between stress and depression. The pro-inflammatory cytokines that respond to stress and answers in patients are increased by psychological stress.
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Copyright (c) 2017 Lilin Rosyanti, Reni Devianti Usman, Indriono Hadi, Syahrianti Syahrianti (Author)
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